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Título

Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila.

AutorGorfinkiel, Nicole ; Martínez Arias, Alfonso
Palabras claveDynamic
Epithelia
Adhesion
Fecha de publicación2007
EditorCompany of Biologists
CitaciónJournal of Cell Science 120: 3289-3298 (2007)
ResumenDynamic interactions between epithelial sheets are a regular feature of morphogenetic processes. Dorsal closure in Drosophila relies on the coordinated movements of two epithelia, the epidermis and the amnioserosa, and provides an excellent model system for a genetic and cell biological approach. Here, we have analyzed the contribution of junctional organization of these epithelia to dorsal closure. We observe a stringent requirement for adherens junctions at the leading edge, the interface between the amnioserosa and the epidermis, for the transmission of the forces generated during the process. We also find that interactionsbetween Armadillo and E-cadherin play an important role in maintaining the adhesion at the leading edge, revealing the particular dynamics of this interface. Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes.
URIhttp://hdl.handle.net/10261/112489
DOI10.1242/jcs.010850
Identificadoresdoi: 10.1242/jcs.010850
issn: 0021-9533
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