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Parallel-stranded hairpins containing 8-aminopurines. Novel efficient probes for triple-helix formation

AuthorsAviñó, Anna; Morales, Juan Carlos; Frieden, Miriam; García de la Torre, Beatriz; Güimil García, Ramón; Cubero, Elena; Luque, Francisco Javier; Orozco, Modesto; Azorín, Ferran ; Eritja Casadellà, Ramón
Issue Date9-Jul-2001
PublisherPergamon Press
CitationBioorganic and Medicinal Chemistry Letters 11(13): 1761-1763 (2001)
AbstractWe describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure. © 2001 Elsevier Science Ltd.
Publisher version (URL)http://dx.doi.org/10.1016/S0960-894X(01)00295-5
Identifiersdoi: 10.1016/S0960-894X(01)00295-5
issn: 0960-894X
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