English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/112455
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing

AutorCosta, Elisabet; Canudas, Silvia; García Bassets, Iván; Pérez, Silvia; Fernández, Irene; Giralt, Ernest; Azorín, Ferran ; Espinàs, Maria Lluïsa
Palabras clavemRNA splicing
Nuclear matrix
Pinin
SAP18
Fecha de publicación12-jul-2006
EditorKluwer Academic Publishers
CitaciónChromosome Research 14(5): 515-526 (2006)
ResumenSAP18 is a highly conserved protein that was proposed to be involved in multiple cellular processes from autophagy to gene regulation and mRNA processing. In this paper we show that, in Drosophila, dSAP18 is a predominantly nuclear protein that associates to both chromosomes and the nuclear matrix. dSAP18 becomes nuclear early during development, at the onset of cellularization, and remains so all through embryo development. dSAP18 is also nuclear in salivary glands, ovaries and cultured S2 cells. Here we also show that dSAP18 forms a complex with the Drosophila homolog of pinin (dPnn), a protein factor involved in mRNA splicing. dSAP18-dPnn interaction was confirmed in vivo, through co-immunoprecipitation experiments, as well as in vitro, through GST pull-down assays. These results are discussed in the context of the possible functions played by SAP18. © Springer 2006.
Versión del editorhttp://dx.doi.org/10.1007/s10577-006-1046-5
URIhttp://hdl.handle.net/10261/112455
DOI10.1007/s10577-006-1046-5
Identificadoresdoi: 10.1007/s10577-006-1046-5
issn: 0967-3849
Aparece en las colecciones: (IBMB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.