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A sentisitive method for the quantification of virion-sense and complementary-sense DNA strands of circular single-stranded DNA viruses

AuthorsRodríguez-Negrete, Edgar A.; Sánchez-Campos, Sonia; Cañizares, M. Carmen; Navas-Castillo, Jesús; Moriones, Enrique; Bejarano, Eduardo R.; Grande-Pérez, Ana
Issue Date22-Sep-2014
PublisherNature Publishing Group
CitationScientific Reports
AbstractCircular singlestranded DNA (ssDNA) viruses are the smallest viruses known to infect eukaryotes. High recombination and mutation rates have conferred these viruses with an evolutionary potential that has facilitated their emergence. Their damaging effects on livestock (circoviruses) and crops (geminiviruses and nanoviruses), and the ubiquity of anelloviruses in human populations and other mammalian species, have resulted in increased interest in better understanding their epidemiology and infection mechanisms. Circular ssDNA viral replication involves the synthesis of dsDNA intermediates containing complementarysense (CS) and virionsense (VS) strands. Precise quantification of VS and CS accumulation during viral infections can provide insights into the molecular mechanisms underlying viral replication and the host invasion process.
Publisher version (URL)http://www.nature.com/srep/2014/140922/srep06438/full/srep06438.html
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