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Title

Endothelial membrane reorganization during leukocyte extravasation

AuthorsReglero-Real, Natalia ; Marcos Ramiro, Beatriz ; Millán, Jaime
KeywordsICAM-1
PECAM-1
Caveolae
Transcellular
Docking structures
Diapedesis
Tetraspanins
Microvilli
Issue Date2012
PublisherBirkhäuser Verlag
CitationCellular and Molecular Life Sciences 69: 3079- 3099 (2012)
AbstractLeukocyte trafficking from the bloodstream to inflamed tissues across the endothelial barrier is an essential response in innate immunity. Leukocyte adhesion, locomotion, and diapedesis induce signaling in endothelial cells and this is accompanied by a profound reorganization of the endothelial cell surfaces that is only starting to be unveiled. Here we review the current knowledge on the leukocytemediated alterations of endothelial membrane dynamics and their role in promoting leukocyte extravasation. The formation of protein- and lipid-mediated cell adhesion nanodomains at the endothelial apical surface, the extension of micrometric apical membrane docking structures, which are derived from microvilli and embrace adhered leukocytes, as well as the vesicle-trafficking pathways that are required for efficient leukocyte diapedesis, are discussed. The coordination between these different endothelial membrane-remodeling events probably provides the road map for transmigrating leukocytes to find exit points in the vessel wall, in a context of severe mechanical and inflammatory stress. A better understanding of how vascular endothelial cells respond to immune cell adhesion should enable new therapeutic strategies to be developed that can abrogate uncontrolled leukocyte extravasation in inflammatory diseases. © Springer Basel AG 2012.
URIhttp://hdl.handle.net/10261/112354
DOI10.1007/s00018-012-0987-4
Identifiersdoi: 10.1007/s00018-012-0987-4
issn: 1420-682X
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