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Title

Endothelial Control of Vasomotor Tone: The Kidney Perspective

AuthorsLamas Peláez, Santiago ; Rodríguez-Puyol, Diego
KeywordsEndothelial dysfunction
Endothelial activation
Nitric oxide
Endothelin
Prostacyclin
Issue Date2012
PublisherW.B. Saunders
CitationSeminars in Nephrology 32: 156- 166 (2012)
AbstractEndothelial cells are essential regulators of vascular tone. They accomplish this by sensing humoral mediators and transducing their effects to the underlying vascular smooth muscle as well as by synthesizing vasoactive molecules that act in a paracrine fashion. In the kidney, the local release of these endothelial mediators, together with the concourse of specialized endothelial cells in the glomerulus, contribute to regulate renal blood flow, glomerular filtration, and tubular function that are intimately linked to sodium balance because they mutually influence each other. Ultimately, renal circulation and tubular function have a profound influence in systemic blood pressure as a result of the overall regulation of volume homeostasis. © 2012 Elsevier Inc.
URIhttp://hdl.handle.net/10261/112352
DOI10.1016/j.semnephrol.2012.02.002
Identifiersdoi: 10.1016/j.semnephrol.2012.02.002
issn: 0270-9295
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