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Title

End-binding protein 1 controls signal propagation from the T cell receptor

AuthorsMartín-Cófreces, Noa; Baixauli, Francesc; López, María J. ; Gil, Diana; Monjas, Alicia; Alarcón, Balbino ; Sánchez-Madrid, Francisco
KeywordsVesicular trafficking
Cytoskeleton
Microtubule dynamics
T cell Activation
Cell signalling
Issue Date2012
PublisherNature Publishing Group
CitationEMBO Journal 31: 4140- 4152 (2012)
AbstractThe role of microtubules (MTs) in the control and dynamics of the immune synapse (IS) remains unresolved. Here, we show that T cell activation requires the growth of MTs mediated by the plus-end specific protein end-binding 1 (EB1). A direct interaction of the T cell receptor (TCR) complex with EB1 provides the molecular basis for EB1 activity promoting TCR encounter with signalling vesicles at the IS. EB1 knockdown alters TCR dynamics at the IS and prevents propagation of the TCR activation signal to LAT, thus inhibiting activation of PLCγ1 and its localization to the IS. These results identify a role for EB1 interaction with the TCR in controlling TCR sorting and its connection with the LAT/PLCγ1 signalosome. © 2012 European Molecular Biology Organization | All Rights Reserved.
URIhttp://hdl.handle.net/10261/112347
DOI10.1038/emboj.2012.242
Identifiersdoi: 10.1038/emboj.2012.242
issn: 0261-4189
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