Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/112296
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Heyn, Holger | - |
dc.contributor.author | Hernando-Herraez, Irene | - |
dc.contributor.author | Marqués-Bonet, Tomàs | - |
dc.contributor.author | Esteller, Manel | - |
dc.date.accessioned | 2015-03-12T12:53:55Z | - |
dc.date.available | 2015-03-12T12:53:55Z | - |
dc.date.issued | 2013 | - |
dc.identifier | doi: 10.1101/gr.154187.112 | - |
dc.identifier | issn: 1088-9051 | - |
dc.identifier | e-issn: 1549-5469 | - |
dc.identifier.citation | Genome Research 23: 1363-1372 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/112296 | - |
dc.description | Heyn, Holger el al.-- This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported). | - |
dc.description.abstract | DNA methylation patterns are important for establishing cell, tissue, and organism phenotypes, but little is known about their contribution to natural human variation. To determine their contribution to variability, we have generated genomescale DNA methylation profiles of three human populations (Caucasian-American, African-American, and Han Chinese-American) and examined the differentially methylated CpG sites. The distinctly methylated genes identified suggest an influence of DNA methylation on phenotype differences, such as susceptibility to certain diseases and pathogens, and response to drugs and environmental agents. DNA methylation differences can be partially traced back to genetic variation, suggesting that differentially methylated CpG sites serve as evolutionarily established mediators between the genetic code and phenotypic variability. Notably, one-third of the DNA methylation differences were not associated with any genetic variation, suggesting that variation in population-specific sites takes place at the genetic and epigenetic levels, highlighting the contribution of epigenetic modification to natural human variation. © 2013, Published by Cold Spring Harbor Laboratory Press. | - |
dc.description.sponsorship | The research leading to these results received funding from the European Research Council (ERC) grant EPINORC under agreement number 268626, ERC Starting Grant (260372), NIH grants CA138461 and GM61388 (Pharmacogenomics Research Network), the MICINN Projects SAF2011-22803 and BFU2011-28549, the Cellex Foundation, the European Community's Seventh Framework Programme (FP7/2007-2013) from grant HEALTH-F5-2011-282510 (BLUEPRINT), and the Health and Science Departments of the Generalitat de Catalunya. I.H.H. is a fellow of the Generalitat de Catalunya (FI 2011). | - |
dc.publisher | Cold Spring Harbor Laboratory Press | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/268626 | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/282510 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | DNA methylation contributes to natural human variation | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1101/gr.154187.112 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1101/gr.154187.112 | - |
dc.date.updated | 2015-03-12T12:53:55Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc/3.0/ | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Fundació Privada Cellex | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.pmid | 23908385 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IBE) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
DNA_methylation_Heyn.pdf | 1,39 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
176
checked on 17-abr-2024
SCOPUSTM
Citations
295
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
264
checked on 29-feb-2024
Page view(s)
390
checked on 19-abr-2024
Download(s)
470
checked on 19-abr-2024