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Title

In vitro antiproliferative activity of thionate platinum(II) and palladium (II) complexes with PTA and DAPTA

AuthorsMendía, Aránzazu; Cerrada, Elena ; Laguna, Mariano
Issue Date2013
CitationISMEC 2013
AbstractSome studies have been focused on the preparation of water-soluble gold, platinum and palladium complexes with satisfactory cytotoxicity results. We have previously reported water-soluble gold(I) and platinum(II) complexes containing heterocyclic thionates [Au(SN)(P)] and trans-[Pt(SN)2(P)2] [SN = C5H4NS (pyridine-2-thionate), C4H3N2S (pyrimidine-2-thionate); P = PTA, PTA], which showed interesting in vitro antitumor properties in a series of tested cancer cell lines [1]. Therefore, we have been interested in synthesizing new water-soluble thionate palladium(II) and platinum(II) derivatives with PTA (1,3,5-triaza-7-phosphaadamantane) and DAPTA (3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo-[3.3.1] nonane). Here we present the preparation and characterization of a series of slightly water-soluble mononuclear thionate Pd(II) and Pt(II) complexes of the type trans-[M(SN)2(P)2] as evidenced by the X-ray structures of six of them. Only [Pd2Cl2(S-2-mercaptopyrimidin-4-one)2(PTA)2] shows a dinuclear structure. The antiproliferative properties of some of these complexes have been tested, and they show in vitro activities (IC50) against a human ovarian cancer cell line A2780 that are comparable to cisplatin, although they are much more efficient against A2780cisR (cisplatin resistant).
DescriptionTrabajo presentado al International Symposium on Metal Complexes celebrado en Burgos (España) del 16 al 20 de junio de 2013.
URIhttp://hdl.handle.net/10261/112209
Appears in Collections:(ISQCH) Comunicaciones congresos
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