English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/112203
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Dicer-1 is a key enzyme in the regulation of oogenesis in panoistic ovaries

AuthorsDonato Tanaca, Erika ; Piulachs, Maria-Dolors
Juvenile hormone
Blattella germanica
Issue DateAug-2012
PublisherJohn Wiley & Sons
CitationBiology of the Cell 104(8): 452-461 (2012)
Abstract[Background information] In insects, the action of microRNAs (miRNAs) on oogenesis has been explored only in dipterans, which possess meroistic ovaries, a highly modified ovarian type. Here we study miRNA function in the most primitive, panoistic type of ovaries using the phylogenetically basal insect Blattella germanica (Dictyoptera, Blattellidae) as model.
[Results] Dicer-1 (Dcr1), a key enzyme in miRNA biogenesis, was depleted using RNAi. Females treated with double-stranded RNA targeting Dicer-1, exhibited deep alterations in oocyte development; among them, the follicular epithelia of the basal oocytes did not develop, thus resulting in sterile females.
[Conclusions] These effects derived from the absence of Dicer-1 suggest that miRNAs are crucial for the regulation of oogenesis in panoistic ovaries, the most primitive insect ovarian type. © 2012 Soçiété Francaise des Microscopies and Société de Biologie Cellulaire de France.
Publisher version (URL)http://dx.doi.org/10.1111/boc.201100044
Identifiersdoi: 10.1111/boc.201100044
issn: 0248-4900
e-issn: 1768-322X
Appears in Collections:(IBE) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.