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Detection and characterization of endogenous retroviruses in the horse genome by in silico analysis

AuthorsGarcia-Etxebarria, Koldo; Jugo, Begoña M.
Endogenous retroviruses
Issue Date5-Dec-2012
CitationVirology 434(1): 59-67 (2012)
AbstractEndogenous retroviruses (ERVs) are proviral phases of exogenous retroviruses that have become incorporated into the host genome. Little is known about ERVs in the horse genome. By combining 3 bioinformatic approaches, we detected 1947 putative ERVs in the horse genome. These equine ERVs are not scattered randomly across the genome and are especially abundant in the X chromosome. Based on phylogenetic relationships, some of these equine ERVs were classified into 15 previously uncharacterized families of Classes I, II and III. Compared with the cow and other species, the horse genome appears to container fewer ERVs. Although this could be due to limitations of the detection process, it could also stem from characteristics of the horse genome or the effect of the domestication process. © 2012 Elsevier Inc.
DescriptionThe final published version is freely available to read and download at the journal's web site.
Publisher version (URL)http://dx.doi.org/10.1016/j.virol.2012.08.047
Identifiersdoi: 10.1016/j.virol.2012.08.047
issn: 0042-6822
Appears in Collections:(IBE) Artículos
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