English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/112139
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

DECR1 and ME1 genotypes are associated with lipid composition traits in Duroc pigs

AuthorsRamírez, Óscar ; Quintanilla, Raquel; Varona, Luis; Gallardo, David ; Díaz, Isabel; Pena, Ramona N.; Amills, Marcel
KeywordsCandidate gene
Fatty acid composition
Cholesterol
Pig
Issue DateFeb-2014
PublisherWiley-Blackwell
CitationJournal of Animal Breeding and Genetics 131(1): 46-52 (2014)
AbstractVariation at the porcine DECR1 and ME1 genes has been associated with meat quality traits and backfat thickness in Landrace pigs, respectively. However, it has not been investigated yet whether DECR1 and ME1 genotypes influence lipid composition. With this aim, we have genotyped two missense DECR1 substitutions (c.160G>C and c.437G>C) and one silent ME1 (c.576C>T) polymorphism in 361 Duroc barrows distributed in five half-sib families and phenotyped for serum lipid concentrations and intramuscular fat content and composition traits. At the whole-population level, relevant associations, that is, with a posterior probability of the allele substitution effect to be over or below zero (PPN0) > 0.90, were observed between DECR1 genotype and serum cholesterol (CHOL) (PPN0 = 0.932) and LDL concentrations (PPN0 = 0.945) at 190 days, as well as between ME1 genotype and longissimus dorsi saturated fatty acid content (PPN0 = 0.924). At the within-family level, we found relevant associations between DECR1 and ME1 genotypes and diverse lipid composition traits, but most of them were family-specific. Discrepancies in allele substitution effects estimated in half-sib families might be produced by many factors such as number of individuals, marker allele frequencies and informativeness in each family, unaccounted random genetic and environmental effects, epistasis and family-specific differences in the linkage phase or amount of linkage disequilibrium between causal and marker mutations. This lack of consistency across families, combined with the fact that the ME1 mutation is synonymous and that the two DECR1 polymorphisms are conservative, suggests that the associations found are not causative. © 2013 Blackwell Verlag GmbH.
Publisher version (URL)http://dx.doi.org/10.1111/jbg.12035
URIhttp://hdl.handle.net/10261/112139
DOI10.1111/jbg.12035
Identifiersdoi: 10.1111/jbg.12035
issn: 0931-2668
e-issn: 1439-0388
Appears in Collections:(CRAG) Artículos
(IBE) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.