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Título

Pursuing enzyme inhibitors through rational design of glycomimetics

Autor Merino, Pedro
Fecha de publicación 2013
Citación TUMA 2013
ResumenThe ongoning progress in protein crystallography and NMR techniques (e.g. STD) provides increasing importance to the structure-based drug design in the search of new therapeutic agents of interest. Starting from the 3D structure of a transglycosylase new molecules have been designed to be complementary to the binding site as well as in the geometry. In addition to an efficient chemical synthesis, based on stereoselective reactions including dipolar cycloadditions and nucloephilic additions to nitrones as well as as simple glycosylation reactions, a variety of structural studies of the potential inhibitors including docking studies and STD-NMR experiments will be presented.
Descripción Trabajo presentado al XXXII Convegno Interregionale delle Sezioni Toscana Umbria Marche Abruzzo della Società Chimica Italiana celebrado en Florencia (Italia) del 1 al 2 de julio de 2013.
URI http://hdl.handle.net/10261/112105
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