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dc.contributor.authorMoreno, Daniel-
dc.contributor.authorKnecht, Erwin-
dc.contributor.authorViollet, Benoit-
dc.contributor.authorSanz, Pascual-
dc.date.accessioned2015-03-10T11:29:01Z-
dc.date.available2015-03-10T11:29:01Z-
dc.date.issued2008-07-23-
dc.identifier.citationFEBS Letters 582(17):2650-4 (2008)es_ES
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10261/112090-
dc.description5 páginas y 4 figuras.es_ES
dc.description.abstractIn this work we present evidence that A769662, a novel activator of AMP-activated protein kinase (AMPK), is able to inhibit the function of the 26S proteasome by an AMPK-independent mechanism. Contrary to the mechanism of action of most proteasome inhibitors, A769662 does not affect the proteolytic activities of the 20S core subunit, defining in this way a novel mechanism of inhibition of 26S proteasome activity. Inhibition of proteasome activity by A769662 is reversible and leads to an arrest of cell cycle progression. These side effects of this new activator of AMPK should be taken into account when this compound is used as an alternative activator of the kinase.es_ES
dc.description.sponsorshipThis work was supported by grants from the CIBER de Enfermedades Raras, an initiative of the ISCIII, and grants from the European Commission (LSHM-CT-2004-005272) to P.S. and from the Spanish Ministry of Education and Science grant (BFU2005-00087) to E.K.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.publisherFederation of European Biochemical Societieses_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccesses_ES
dc.subjectA769662es_ES
dc.subjectAMPKes_ES
dc.subject26S Proteasomees_ES
dc.subjectInhibitores_ES
dc.subjectProtein degradationes_ES
dc.titleA769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanismes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.febslet.2008.06.044-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.febslet.2008.06.044es_ES
dc.identifier.e-issn1873-3468-
dc.relation.csices_ES
dc.identifier.pmid18593584-
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