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Gold(I) complexes with optimum hydrophillic/lipophillic balance as anticancer drugs

AuthorsAtrián-Blasco, Elena ; García-Moreno, Elena; Gascón, Sonia; Cerrada, Elena ; Rodríguez-Yoldi, Mª. Jesus; Laguna, Mariano
Issue Date2013
CitationXII International Symposium on Inorganic Biochemistry (2013)
AbstractAuranofin is the best example of gold complexes used in medicine. And since the success of cisplatin as a chemotherapeutic agent, gold has become one of the most studied metals with potential anticancer activity. However, these drugs have undesired side effects, which in the case of metallic complexes, could be caused by their lipophilicity. In order to achieve an optimum lipophilic/hydrophilic balance, water soluble phosphanes derived from PTA (1,3,5-triaza-7-phosphadamantane) have been used to synthesise different gold (I) complexes, including gold thiolates. The antitumor activity of some of these complexes has been studied against human color cancer cell lines.
DescriptionTrabajo presentado al XII International Symposium on Inorganic Biochemistry: Collaboration and Beyond, celebrado en Wroclaw (Polonia) del 28 de agosto al 1 de septiembre de 2013.
Appears in Collections:(ISQCH) Comunicaciones congresos
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