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Title

Upstream deregulation of calcium signaling in Parkinson’s disease

AuthorsRivero-Ríos, Pilar; Gómez-Suaga, P.; Fdez, Elena; Hilfiker, Sabine
KeywordsParkinson’s disease
dopamine
calcium
mitochondria
endoplasmic reticulum
lysosomes
Golgi
Issue Date17-Jun-2014
PublisherFrontiers Media
CitationFrontiers in Molecular Neuroscience
AbstractParkinson’s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca2+ stress which may determine their selective vulnerability, and suggest how abnormal Ca2+ handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental, and genetic stress. Gaining a better understanding of the varied effects of Ca2+ dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression.
Publisher version (URL)http://journal.frontiersin.org/article/10.3389/fnmol.2014.00053/full#h11
URIhttp://hdl.handle.net/10261/112067
DOIhttp://dx.doi.org/10.3389/fnmol.2014.00053
ISSN1662-5099
E-ISSN1662-5099
Appears in Collections:(IPBLN) Artículos
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