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Title

Role of AMP-activated protein kinase in autophagy and proteasome function

AuthorsViana, Rosa ; Aguado, Carmen; Esteban, Inmaculada; Moreno, Daniel; Viollet, Benoit; Knecht, Erwin; Sanz, Pascual
KeywordsAICAR
AMPK
Proteasome
PI3-kinase
Protein degradation
Autophagy
Issue Date9-May-2008
PublisherElsevier
CitationBiochemical and Biophysical Research Communications 369(3):964-968. (2008)
AbstractIn this work, we have examined the possible role of AMP-activated protein kinase (a key energy sensor) in regulating intracellular protein degradation. We have found that AICAR, a known activator of AMPK, has a dual effect. On one hand, it inhibits autophagy by a mechanism independent of AMPK activity; AICAR decreases class III PI3-kinase binding to beclin-1 and this effect counteracts and reverses the known positive effect of AMPK activity on autophagy. On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand.
Description5 páginas, 4 figuras
Publisher version (URL)http://dx.doi.org/10.1016/j.bbrc.2008.02.126
URIhttp://hdl.handle.net/10261/112050
DOI10.1016/j.bbrc.2008.02.126
ISSN0006-291X
E-ISSN1090-2104
Appears in Collections:(IBV) Artículos
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