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Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9

AutorHerraiz, Alba ; Bellés, Xavier ; Piulachs, Maria-Dolors
Palabras claveH3K9me3
Follicular epithelia
Drosophila
Oogenesis
Blattella germanica
Fecha de publicación1-ene-2014
EditorElsevier
CitaciónExperimental Cell Research 320(1): 46-53 (2014)
ResumenEpigenetic modifications play key roles in transcriptional regulation. Trimethylation of histone 3 lysine 9 (H3K9me3) is one of the most widely studied histone post-translational modifications, and has been linked to transcriptional repression. In Drosophila melanogaster, Windei is needed for H3K9me3 in female germ line cells. Here, we report the occurrence of a D. melanogaster Windei (Wde) ortholog in the ovary of the hemimetabolous insect Blattella germanica, which we named BgWde. Depletion of BgWde by RNAi reduced H3K9me3 in follicular cells, which triggered changes in transcriptional regulation that led to the prevention of chorion gene expression. In turn, this impaired oviposition (and the formation of the ootheca) and, therefore, prevented reproduction. Windei and H3K9me3 have already been reported in follicular cells of D. melanogaster, but this is the first time that the function of these modifications has been demonstrated in the said cells. This is also the first time that an epigenetic marker is reported as having a key role in choriogenesis. © 2013 Elsevier Inc.
Versión del editorhttp://dx.doi.org/10.1016/j.yexcr.2013.07.006
URIhttp://hdl.handle.net/10261/111867
DOI10.1016/j.yexcr.2013.07.006
Identificadoresdoi: 10.1016/j.yexcr.2013.07.006
issn: 0014-4827
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