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SREBP-2-mediated cholesterol accumulation regulates beta-amyloid-induced autophapy in APP/PS1/SREBP-2 mice

AuthorsBarbero-Camps, Elisabet ; Fernández-Checa, José C. ; Colell Riera, Anna
Issue Date14-Jul-2013
PublisherAlzheimer’s Association
CitationAlzheimer's and Dementia 9(4, Supplement): P194-P195 (2013)
AbstractAberrant autophagy in Alzheimer's Disease (AD) is evidenced by a massive build-up of autophagy intermediates, suggesting increased autophagosome formation or defective progression to autophagolysosomes. To date, the exact mechanisms that led to this dysfunction are unknown; however, as similar defects are observed in Niemann-Pick type C1 knockout mice, which accumulate cholesterol in late endosomes/lysosomes, we hypothesize that the impaired cholesterol homeostasis described in AD may play a role
DescriptionComunicación presentada en la Alzheimer's Association 2013 International Conference, celebrada del 13 al 18 de julio de 2013 en Boston (Estados Unidos)
Publisher version (URL)http://dx.doi.org/10.1016/j.jalz.2013.05.343
Identifiersdoi: 10.1016/j.jalz.2013.05.343
issn: 1552-5260
Appears in Collections:(IIBB) Comunicaciones congresos
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