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Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity

AuthorsColell Riera, Anna ; García-Ruiz, Carmen ; Marí, Montserrat ; Fernández-Checa, José C.
KeywordsGanglioside GD3
Oxidative stress
Mitochondrial glutathione
Issue Date27-Feb-2004
CitationFEBS Letters 560(1-3): 63-68 (2004)
AbstractCholesterol enrichment of rat liver mitochondria (CHM) impairs atractyloside-induced mitochondrial permeability transition (MPT) due to decreased membrane fluidity. In this study we addressed the effect of cholesterol enrichment on MPT induced by reactive oxygen species (ROS). Superoxide anion generated by xanthine plus xanthine oxidase triggered mitochondrial swelling and cytochrome c release in CHM, which was prevented by butylated hydroxytoluene, an anti-voltage-dependent anion channel antibody, or cyclosporin A. Furthermore, hydrogen peroxide generated by the combination of ganglioside GD3 and mitochondrial GSH depletion elicited mitochondrial swelling and release of cytochrome c, Smac/Diablo and apoptosis-inducing factor in control mitochondria and CHM. Thus, ROS induce MPT and apoptosome activation regardless of decreased mitochondrial membrane dynamics due to cholesterol enrichment. © 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Publisher version (URL)http://dx.doi.org/10.1016/S0014-5793(04)00071-7
Identifiersdoi: 10.1016/S0014-5793(04)00071-7
issn: 0014-5793
Appears in Collections:(IIBB) Artículos
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