English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/111726
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


HIV-1 inhibiting capacity of novel forms of presentation of GB virus C peptide domains is enhanced by coordination to gold compounds

AuthorsGómara Elena, María José ; Galatola, Ramona ; Gutiérrez, Alejandro ; Gimeno, M. Concepción ; Gatell, José M.; Sánchez-Merino, Víctor; Yuste, Eloísa; Haro Villar, Isabel
KeywordsCyclic peptides
Cell–cell fusion assays
Peptide–gold complexes
Multiple antigenic peptides
Anti-HIV assays
Issue Date2014
PublisherBentham Science Publishers
CitationCurrent Medicinal Chemistry 21(2): 238-250 (2014)
AbstractFollowing the report of beneficial effects of co-infection by GB virus C (GBV-C) for HIV-infected patients, we have studied synthetic GBV-C peptides and their relationship with HIV type-1. This paper reports the design and synthesis of new forms of presentation of two peptide inhibitors corresponding to the envelope proteins E1 and E2 of GBV-C, together with a study of their anti-HIV-1 activity. Homogeneous and heterogeneous multiple antigenic peptides (MAPs), lipophilic derivatizations, cyclization and peptide-gold conjugations are the chemical design strategies adopted. Our aim is to enhance the anti-viral potency of the GBV-C peptide domains. Of all the GBV-C peptide derivatives studied, peptide- gold complexes derived from the (22-39) sequence of the GBV-C E1 protein were the most active entry inhibitors. These results support the putative modulation of HIV-1 infection by the GBV-C E1 protein and open new perspectives for the development of novel peptide-derived HIV-1 entry inhibitors. © 2014 Bentham Science Publishers.
Identifiersdoi: 10.2174/09298673113206660276
issn: 0929-8673
e-issn: 1875-533X
Appears in Collections:(IQAC) Artículos
(ISQCH) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.