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Título

Organocatalytic enantioselective hydrophosphonylation of aldehydes

AutorAlegre-Requena, Juan V. ; Marqués-López, Eugenia ; Sanz Miguel, Pablo J. ; Herrera, Raquel P.
Fecha de publicación2014
EditorRoyal Society of Chemistry (Great Britain)
CitaciónOrganic and Biomolecular Chemistry 12(8): 1258-1264 (2014)
ResumenWe report our results concerning the first squaramide-catalysed hydrophosphonylation of aldehydes. In all cases, the reactions proceeded smoothly and cleanly under mild reaction conditions rendering final α-hydroxy phosphonates in very good yields and high enantioselectivities. It is one of the few organocatalytic examples of this reaction using aldehydes. It is the first time that diphenylphosphite (1e) has been successfully employed in a chiral Pudovik reaction with aldehydes, in contrast to the dialkylphosphites used in previously published procedures, extending the generality of this asymmetric methodology. © 2014 The Royal Society of Chemistry.
Versión del editorhttp://dx.doi.org/10.1039/C3OB42403K
URIhttp://hdl.handle.net/10261/111669
DOI10.1039/C3OB42403K
Identificadoresdoi: 10.1039/C3OB42403K
issn: 1477-0520
e-issn: 1477-0539
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