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Título

Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine

Autor Bosch Morell, Francisco; Martínez-Soriano, Francisco; Colell Riera, Anna ; Fernández-Checa, José C. ; Romero, Francisco. J.
Palabras clave Nerve
N-acetyl-L- cysteine
Glutathione
Ethano
Antioxidants
S-adenosyl-L-methionine
Glutathione peroxidase
Malondialdehyde
Free radical
Fecha de publicación ago-1998
EditorElsevier
Citación Free Radical Biology and Medicine 25(3): 365-368 (1998)
ResumenChronic ethanol feeding promotes oxidative stress in rat peripheral nerve. Malondialdehyde, a lipid peroxidation product, content increases in sciatic nerves of rats fed an ethanol-containing diet, when compared with pair-fed animals. Moreover, glutathione content and glutathione peroxidase activity in this same tissue decrease in ethanol-fed vs. pair-fed rats. S- adenosyl-L-methionine and N-acetyl-L-cysteine, both with possible therapeutic action on alcoholism, were tested in this animal model. Only N-acetyl-L- cysteine was able to normalize malondialdehyde content and to restore glutathione content and glutathione peroxidase activity, to values not significantly different from those of sciatic nerves from pair-fed animals. The reasons for the different effect of both substances tested is also discussed.
Versión del editorhttp://dx.doi.org/10.1016/S0891-5849(98)00036-7
URI http://hdl.handle.net/10261/111560
DOI10.1016/S0891-5849(98)00036-7
Identificadoresdoi: 10.1016/S0891-5849(98)00036-7
issn: 0891-5849
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