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A proteomic approach to iron and copper homeostasis in cyanobacteria

AutorCerda, Berta de la ; Castielli, Ornella ; Durán, Raúl V.; Navarro, José A. ; Hervás, Manuel ; Rosa, Miguel A. de la
Palabras claveProteomics
Iron homeostasis
Copper homeostasis
Fecha de publicacióndic-2007
EditorOxford University Press
CitaciónBriefings in Functional Genomics and Proteomics 6(4): 322-329 (2007)
ResumenCyanobacteria, which are considered to be the chloroplast precursors, are significant contributors to global photosynthetic productivity. The ample variety of membrane and soluble proteins containing different metals (mainly, iron and copper) has made these organisms develop a complex homeostasis with different mechanisms and tight regulation processes to fulfil their metal requirements in a changing environment. Cell metabolism is so adapted as to synthesize alternative proteins depending on the relative metal availabilities. In particular, plastocyanin, a copper protein, and cytochrome c6, a haem protein, can replace each other to play the same physiological role as electron carriers in photosynthesis and respiration, with the synthesis of one protein or another being regulated by copper concentration in the medium. The unicellular cyanobacterium Synechocystis sp. PCC 6803 has been widely used as a model system because of completion of its genome sequence and the ease of its genetic manipulation, with a lot of proteomic work being done. In this review article, we focus on the functional characterization of knockout Synechocystis mutants for plastocyanin and cytochrome c6, and discuss the ongoing proteomic analyses performed at varying copper concentrations to investigate the cyanobacterial metal homeostasis and cell response to changing environmental conditions.
Descripción8 pages, 2 figures.-- PMID: 18192321 [PubMed].
Versión del editorhttp://dx.doi.org/10.1093/bfgp/elm030
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