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Título: | Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels |
Autor: | Carretón, Olga; Giralt, Albert; Torres-Peraza, Jesús F. CSIC; Brito, Verónica; Lucas, José Javier CSIC ORCID; Ginés, Silvia; Canals, Josep María; Alberch, Jordi CSIC | Palabras clave: | Spinophilin GluR1 Dendritic spine BDNF heterozygous mice |
Fecha de publicación: | 2012 | Editor: | Academic Press | Citación: | Experimental Neurology 237: 335- 345 (2012) | Resumen: | Brain-derived neurotrophic factor (BDNF) is a key player in learning and memory processes. However, little is known about brain area-specific functions of this neurotrophin. Here we investigated whether BDNF could differently affect motor neocortical and hippocampal-related cognitive and plastic morphologic changes in young (12-week-old) and middle-aged (30-week-old) BDNF heterozygous (BDNF +/-) and wild type (wt) mice. We found that at 30weeks of age, BDNF +/- mice showed impaired performance in accelerating rotarod and grasping tests while preserved spatial learning in a T-maze and recognition memory in an object recognition task compared with wt mice suggesting a specific neocortical dysfunction. Accordingly, a significant reduction of synaptic markers (PSD-95 and GluR1) and corresponding puncta was observed in motor neocortex but not in hippocampus of BDNF +/- mice. Interestingly, 30-week-old BDNF +/- mice displayed increased TrkB levels in the hippocampus but not in the motor neocortex, which suggests specific hippocampal compensatory mechanisms as a consequence of BDNF decrease. In conclusion, our data indicates that BDNF could differentially regulate the neuronal micro-structures and cognition in a region-specific and in an age-dependent manner. © 2012 Elsevier Inc. | URI: | http://hdl.handle.net/10261/111384 | DOI: | 10.1016/j.expneurol.2012.06.033 | Identificadores: | doi: 10.1016/j.expneurol.2012.06.033 issn: 0014-4886 |
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