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Title

A genome-wide survey does not show the genetic distinctiveness of Basques

AuthorsLaayouni, Hafid ; Calafell, Francesc ; Bertranpetit, Jaume
Issue DateApr-2010
PublisherSpringer
CitationHuman Genetics 127(4): 455-458 (2010)
AbstractBasques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F ST distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised. © 2010 Springer-Verlag.
Publisher version (URL)http://dx.doi.org/10.1007/s00439-010-0798-3
URIhttp://hdl.handle.net/10261/111349
DOI10.1007/s00439-010-0798-3
Identifiersdoi: 10.1007/s00439-010-0798-3
issn: 0340-6717
e-issn: 1432-1203
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