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A comprehensive model of the phototransduction cascade in mouse rod cells

AutorInvergo, Brandon M. ; Dell’Orco, Daniele; Montanucci, Ludovica ; Koch, Karl-Wilhelm; Bertranpetit, Jaume
Fecha de publicaciónmar-2014
EditorRoyal Society of Chemistry (Great Britain)
CitaciónMolecular BioSystems 10: 1481-1489 (2014)
ResumenVertebrate visual phototransduction is perhaps the most well-studied G-protein signaling pathway. A wealth of available biochemical and electrophysiological data has resulted in a rich history of mathematical modeling of the system. However, while the most comprehensive models have relied upon amphibian biochemical and electrophysiological data, modern research typically employs mammalian species, particularly mice, which exhibit significantly faster signaling dynamics. In this work, we present an adaptation of a previously published, comprehensive model of amphibian phototransduction that can produce quantitatively accurate simulations of the murine photoresponse. We demonstrate the ability of the model to predict responses to a wide range of stimuli and under a variety of mutant conditions. Finally, we employ the model to highlight a likely unknown mechanism related to the interaction between rhodopsin and rhodopsin kinase. © 2014 the Partner Organisations.
DescripciónThis article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Versión del editorhttp://dx.doi.org/10.1039/c3mb70584f
Identificadoresdoi: 10.1039/c3mb70584f
e-issn: 1742-2051
issn: 1742-206X
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