English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/111253
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
Citado 0 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL

A broad genomic survey reveals multiple origins and frequent losses in the evolution of respiratory hemerythrins and hemocyanins

AutorMartín Durán, José M.; Mendoza, Alex de ; Sebé-Pedrós, Arnau ; Ruiz-Trillo, Iñaki ; Hejnol, Andreas
Palabras claveHemocyanin
Lateral gene transfer
Comparative genomics
Fecha de publicaciónjul-2013
EditorOxford University Press
CitaciónGenome Biology and Evolution 5(7): 1435-1442 (2013)
ResumenHemerythrins and hemocyanins are respiratory proteins present in some of the most ecologically diverse animal lineages; however, the precise evolutionary history of their enzymatic domains (hemerythrin, hemocyanin M, and tyrosinase) is still not well understood. We survey a wide dataset of prokaryote and eukaryote genomes and RNAseq data to reconstruct the phylogenetic origins of these proteins. We identify new species with hemerythrin, hemocyanin M, and tyrosinase domains in their genomes, particularly within animals, and demonstrate that the current distribution of respiratory proteins is due to several events of lateral gene transfer and/or massive gene loss. We conclude that the last common metazoan ancestor had at least two hemerythrin domains, one hemocyanin M domain, and six tyrosinase domains. The patchy distribution of these proteins among animal lineages can be partially explained by physiological adaptations, making these genes good targets for investigations into the interplay between genomic evolution and physiological constraints. © The Author(s) 2013.
DescripciónThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited
Versión del editorhttp://dx.doi.org/10.1093/gbe/evt102
Identificadoresdoi: 10.1093/gbe/evt102
issn: 1759-6653
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
broad_genomic_Martin.pdf487,36 kBAdobe PDFVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.