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Título

1000 Genomes Selection Browser 1.0: A genome browser dedicated to signatures of natural selection in modern humans

Autor Pybus, Marc ; Dall'Olio, Giovanni Marco; Luisi, Pierre ; Uzkudun, Manu; Carreño Torres, Ángel ; Pavlidis, Pavlos; Laayouni, Hafid ; Bertranpetit, Jaume ; Engelken, Johannes
Fecha de publicación 1-ene-2014
EditorOxford University Press
Citación Nucleic Acids Research 42(D1): D903-D909 (2014)
ResumenSearching for Darwinian selection in natural populations has been the focus of a multitude of studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 (http://hsb.upf.edu) as a resource for signatures of recent natural selection in modern humans. We have implemented and applied a large number of neutrality tests as well as summary statistics informative for the action of selection such as Tajima's D, CLR, Fay and Wu's H, Fu and Li's F* and D*, XPEHH, ΔiHH, iHS, FST, ΔDAF and XPCLR among others to low coverage sequencing data from the 1000 genomes project (Phase 1; release April 2012). We have implemented a publicly available genome-wide browser to communicate the results from three different populations of West African, Northern European and East Asian ancestry (YRI, CEU, CHB). Information is provided in UCSC-style format to facilitate the integration with the rich UCSC browser tracks and an access page is provided with instructions and for convenient visualization. We believe that this expandable resource will facilitate the interpretation of signals of selection on different temporal, geographical and genomic scales. © 2013 The Author(s). Published by Oxford University Press.
Descripción This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Versión del editorhttp://doi.org/10.1093/nar/gkt1188
URI http://hdl.handle.net/10261/111249
DOI10.1093/nar/gkt1188
Identificadoresissn: 0305-1048
e-issn: 1362-4962
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