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Title

A new biocompatible and antibacterial phosphate free glass-ceramic for medical applications

AuthorsCabal, Belén CSIC ORCID ; Alou, Luis; Cafini, Fabio; Couceiro, Ramiro; Sevillano, David; Esteban-Tejeda, Leticia CSIC; Guitián, Francisco; Torrecillas, Ramón CSIC ORCID CVN; Moya, J. S. CSIC
Issue Date2014
PublisherNature Publishing Group
CitationScientific Reports 4: 5440 (2014)
AbstractIn the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.
DescriptionThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License.
Publisher version (URL)http://dx.doi.org/10.1038/srep05440
URIhttp://hdl.handle.net/10261/110817
DOI10.1038/srep05440
Identifiersdoi: 10.1038/srep05440
issn: 2045-2322
Appears in Collections:(ICMM) Artículos
(CINN) Artículos




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