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Título

Wnt pathway at a glance: From the deep of the crypts to the current ways of targeting

AutorBarbáchano, Antonio ; Larriba, María Jesús ; Ferrer-Mayorga, Gemma ; Muñoz Terol, Alberto ; González-Sancho, José Manuel
Palabras claveWnt
β-catenin
Intestine stem cells
Colon cancer
Cancer stem cells
Wnt inhibitors
Fecha de publicación2014
EditorSpringer
CitaciónStem Cells in Cancer: Should We Believe or Not? (Cap.4): 85-106 (2014)
ResumenWnt/β-catenin signalling pathway is crucial for the formation of many tissues and organs during development. In recent years, this pathway has also been found to regulate the biology of stem cells in the intestine and probably in other organs in adult life. Abnormal activation of Wnt/β-catenin signalling, which controls the expression of a high number of genes, is critical for the initiation and progression of most colorectal cancers. In line with this, the gene expression signature induced by activation of the Wnt/β-catenin pathway defines the intestinal stem cells present at the bottom of the crypts and also colon cancer stem cells. This supports the importance of inhibitors of the Wnt/β-catenin pathway as potential agents in colorectal cancer therapy. However, the complexity, wide activity in the organism modulating the biology of several cell types, and characteristics of this pathway have delayed the identification of suitable targets and so, the development of such inhibitors that are only now reaching the clinic.
Versión del editorhttp://dx.doi.org/10.1007/978-94-017-8754-3_4
URIhttp://hdl.handle.net/10261/110732
DOI10.1007/978-94-017-8754-3_4
ISBN978-94-017-8753-6
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