English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/110091
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Antigenically profound amino acid substitutions occur during large population passages of foot-and-mouth disease virus

AuthorsSevilla, Noemí ; Verdaguer, Núria ; Domingo, Esteban
Issue Date15-Nov-1996
PublisherAcademic Press
CitationVirology 225(2): 400-405 (1996)
AbstractFoot-and-mouth disease virus (FMDV) with amino acid substitutions next to the highly conserved R-G-D motif were isolated following large population passages of the virus (N. Sevilla and E. Domingo, 1996, J. Virol., in press). Reactivity with a panel of monoclonal antibodies which recognize different epitopes within site A was abolished or highly diminished in the mutants. This provides direct evidence of a drastic antigenic change occurring in the absence of selection by antibodies. Molecular modeling studies predict only minor alterations in the conformation of the G-H loop of VP1 and the R-G-D motif in these mutants. None of these variants became dominant in many serial infections involving smaller FMDV population numbers. In addition to documenting profound antigenic variation without immune selection, the results suggest that the repertoire of antigenic variants evolving in viral quasispecies may be greatly influenced by the population size of the virus.
Publisher version (URL)http://dx.doi.org/10.1006/viro.1996.0615
Identifiersdoi: 10.1006/viro.1996.0615
issn: 0042-6822
Appears in Collections:(CBM) Artículos
(CID) Artículos
(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.