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Título

Use of alginate, chitosan and cellulose nanocrystals as emulsion stabilizers in the synthesis of biodegradable polymeric nanoparticles

Autor Rescignano, Nicoletta ; Fortunati, E.; Armentano, Ilaria; Hernández, R.; Mijangos, Carmen ; Pasquino, R.; Kenny, José María
Palabras clave Biodegradable nanoparticles
Poly(dl-Lactide-co-Glycolide)
Emulsion stabilizer
Chitosan
Cellulose nanocrystals
Sodium alginate
Fecha de publicación 2015
EditorElsevier
Citación Journal of Colloid and Interface Science 445: 31-39 (2015)
ResumenBiopolymeric nanoparticles (NPs) based on a biodegradable poly(dl-Lactide-co-Glycolide) PLGA copolymer matrix combined with alginate, chitosan and nanostructured cellulose crystals as three different natural emulsion stabilizers, were synthesized by a double emulsion (water/oil/water) method with subsequent solvent evaporation. The morphological, thermal, chemical and rheological properties of the novel designed NPs and the effect of the different emulsion stabilizers used during the synthesis were deeply investigated in order to optimize the synthesis procedure and the development of biodegradable nanoparticles coated with natural polymers. The morphological analysis of the produced nanoparticles showed that all the different formulations presented a spherical shape with smooth surface. Infrared spectroscopy investigations showed that the PLGA copolymer maintained its backbone structure and confirmed the presence of chitosan, alginate and cellulose nanocrystals (CNC) on the nanoparticle surface. The obtained results suggest that PLGA nanoparticles with CNC as emulsion stabilizer might represent promising formulations opening new perspective in the field of self-assembly of biodegradable nanomaterials for medical and pharmaceutical applications.
URI http://hdl.handle.net/10261/110076
DOI10.1016/j.jcis.2014.12.032
Identificadoresdoi: 10.1016/j.jcis.2014.12.032
issn: 0021-9797
e-issn: 1095-7103
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