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DC Field	Value	Language
dc.contributor.author	Alba-Castellón, L.	-
dc.contributor.author	Loubat, Jordina	-
dc.contributor.author	Muñoz Terol, Alberto	-
dc.contributor.author	Bonilla, Félix	-
dc.contributor.author	Casal, J. Ignacio	-
dc.contributor.author	García de Herreros, Antonio	-
dc.date.issued	2014-05	-
dc.identifier.citation	Neoplasia 16(5): 413–421 (2014)	es_ES
dc.identifier.issn	1522-8002	-
dc.identifier.uri	http://hdl.handle.net/10261/110067	-
dc.description	Under a Creative Commons license.-- et al.	es_ES
dc.description.abstract	Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of mesenchymal stem cells (MSCs), preventing their premature differentiation. Now, we show that Snail1 controls the tumorigenic properties of mesenchymal cells. Increased Snail1 expression provides tumorigenic capabilities to fibroblastic cells; on the contrary, Snail1 depletion decreases tumor growth. Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor downregulates MSC markers and prevents the capability of these cells to originate sarcomas in immunodeficient SCID mice. Notably, an analysis of human sarcomas shows that, contrarily to epithelial tumors, these neoplasms display high Snail1 expression. This is particularly clear for undifferentiated tumors, 9which are associated with poor outcome. Together, our results indicate a role for Snail1 in the generation of sarcomas.	es_ES
dc.description.sponsorship	This study was funded by grants awarded by la Fundación Científica de la Asociación Española contra el Cáncer (to A.G.H., J.I.C., and F.B.), Fundación Sandra Ibarra and Ministerio de Ciencia y Tecnología (SAF2010-16089) to A.G.H. and also by RD12/0036/0005, part of “Plan Nacional de I+D+I” and cofunded by “Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER)”. We also acknowledge support from Fundació La Marató de TV3 (120130), to A.G.H., ISCIII/FEDER (RD12/0036/041, RD12/0036/051, and RD12/0036/021), Generalitat de Catalunya (2009SGR867 and 2009SGR321; Xarxa de Bancs de Tumors), CAM (CAM S2010-BMD2344-Colomics2), and Fundació Cellex (Barcelona). R.B. and L.A.-C. were recipients from “Formación de Personal Investigador” predoctoral fellowships.	-
dc.language.iso	eng	es_ES
dc.publisher	Elsevier	es_ES
dc.relation	S2010-BMD2344-COLOMICS2	-
dc.relation.isversionof	Publisher's version	-
dc.rights	openAccess	es_ES
dc.title	Snail1 expression is required for sarcomagenesis	es_ES
dc.type	artículo	es_ES
dc.identifier.doi	10.1016/j.neo.2014.05.002	-
dc.description.peerreviewed	Peer reviewed	es_ES
dc.relation.publisherversion	http://dx.doi.org/10.1016/j.neo.2014.05.002	es_ES
dc.identifier.e-issn	1476-5586	-
dc.rights.license	http://creativecommons.org/licenses/by-nc-nd/3.0/	es_ES
dc.contributor.funder	Comunidad de Madrid	-
dc.contributor.funder	Fundación Científica Asociación Española Contra el Cáncer	-
dc.contributor.funder	Fundación Sandra Ibarra - Solidaridad Frente al Cáncer	-
dc.contributor.funder	Ministerio de Ciencia y Tecnología (España)	-
dc.contributor.funder	Instituto de Salud Carlos III	-
dc.contributor.funder	Fundació La Marató de TV3	-
dc.contributor.funder	European Commission	-
dc.contributor.funder	Fundació Privada Cellex	-
dc.contributor.funder	Generalitat de Catalunya	-
dc.contributor.funder	Consejo Superior de Investigaciones Científicas (España)	-
dc.relation.csic	Sí	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/501100002704	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/501100007649	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/501100006280	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/501100004587	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/100008666	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/501100000780	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/501100002809	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/501100003339	es_ES
dc.identifier.funder	http://dx.doi.org/10.13039/100012818	es_ES
Appears in Collections:	(IIBM) Artículos (CIB) Artículos