English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/110067
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorAlba-Castellón, L.-
dc.contributor.authorLoubat, Jordina-
dc.contributor.authorMuñoz Terol, Alberto-
dc.contributor.authorBonilla, Félix-
dc.contributor.authorCasal, J. Ignacio-
dc.contributor.authorGarcía de Herreros, Antonio-
dc.date.issued2014-05-
dc.identifier.citationNeoplasia 16(5): 413–421 (2014)es_ES
dc.identifier.issn1522-8002-
dc.identifier.urihttp://hdl.handle.net/10261/110067-
dc.descriptionUnder a Creative Commons license.-- et al.es_ES
dc.description.abstractSnail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of mesenchymal stem cells (MSCs), preventing their premature differentiation. Now, we show that Snail1 controls the tumorigenic properties of mesenchymal cells. Increased Snail1 expression provides tumorigenic capabilities to fibroblastic cells; on the contrary, Snail1 depletion decreases tumor growth. Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor downregulates MSC markers and prevents the capability of these cells to originate sarcomas in immunodeficient SCID mice. Notably, an analysis of human sarcomas shows that, contrarily to epithelial tumors, these neoplasms display high Snail1 expression. This is particularly clear for undifferentiated tumors, 9which are associated with poor outcome. Together, our results indicate a role for Snail1 in the generation of sarcomas.es_ES
dc.description.sponsorshipThis study was funded by grants awarded by la Fundación Científica de la Asociación Española contra el Cáncer (to A.G.H., J.I.C., and F.B.), Fundación Sandra Ibarra and Ministerio de Ciencia y Tecnología (SAF2010-16089) to A.G.H. and also by RD12/0036/0005, part of “Plan Nacional de I+D+I” and cofunded by “Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER)”. We also acknowledge support from Fundació La Marató de TV3 (120130), to A.G.H., ISCIII/FEDER (RD12/0036/041, RD12/0036/051, and RD12/0036/021), Generalitat de Catalunya (2009SGR867 and 2009SGR321; Xarxa de Bancs de Tumors), CAM (CAM S2010-BMD2344-Colomics2), and Fundació Cellex (Barcelona). R.B. and L.A.-C. were recipients from “Formación de Personal Investigador” predoctoral fellowships.-
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationS2010-BMD2344-COLOMICS2-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccesses_ES
dc.titleSnail1 expression is required for sarcomagenesises_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.neo.2014.05.002-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.neo.2014.05.002es_ES
dc.identifier.e-issn1476-5586-
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderFundación Científica Asociación Española Contra el Cáncer-
dc.contributor.funderFundación Sandra Ibarra - Solidaridad Frente al Cáncer-
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderFundació La Marató de TV3-
dc.contributor.funderEuropean Commission-
dc.contributor.funderFundació Privada Cellex-
dc.contributor.funderGeneralitat de Catalunya-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002704es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007649es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006280es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008666es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
Appears in Collections:(IIBM) Artículos
(CIB) Artículos
Files in This Item:
File Description SizeFormat 
Neoplasia 2014, 16 (5) 413-421 J. Ignacio Casal.pdf3,48 MBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.