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http://hdl.handle.net/10261/110035
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dc.contributor.author | Matos, M. J. | - |
dc.contributor.author | Rodríguez-Enríquez, F. | - |
dc.contributor.author | Vilar, S. | - |
dc.contributor.author | Santana, Lourdes | - |
dc.contributor.author | Uriarte, E. | - |
dc.contributor.author | Hripcsak, G. | - |
dc.contributor.author | Estrada, Martín | - |
dc.contributor.author | Rodríguez-Franco, María Isabel | - |
dc.contributor.author | Viña, D. | - |
dc.date.accessioned | 2015-02-02T10:19:29Z | - |
dc.date.available | 2015-02-02T10:19:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier | doi: 10.1016/j.bmcl.2014.12.001 | - |
dc.identifier | issn: 0960-894X | - |
dc.identifier | e-issn: 1464-3405 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters 25: 642-648 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/110035 | - |
dc.description.abstract | In this study we synthesized and evaluated a new series of amino and nitro 3-arylcoumarins as hMAO-A and hMAO-B inhibitors. Compounds 2, 3, 5 and 6 presented a better activity and selectivity profile against the hMAO-B isoform (IC50 values between 2 and 6 nM) than selegiline. In general, the amino derivatives (4-6) proved to be more selective against MAO-B than the nitro derivatives (1-3). Additionally, a theoretical study of some physicochemical properties, PAMPA and reversibility assays for the most potent derivative, and molecular docking simulations were carried out to further explain the pharmacological results, and to identify the hypothetical binding mode for the compounds inside the hMAO-B. | - |
dc.publisher | Elsevier | - |
dc.rights | openAccess | - |
dc.subject | 3-Arylcoumarins | - |
dc.subject | Perkin reaction | - |
dc.subject | Monoamine oxidase inhibitors | - |
dc.subject | PAMPA assay | - |
dc.subject | ADME theoretical properties | - |
dc.subject | Docking studies | - |
dc.title | Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.bmcl.2014.12.001 | - |
dc.date.updated | 2015-02-02T10:19:29Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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Publ 66 (Potent and selective MAO-B inhibitory activity).pdf | 387,01 kB | Adobe PDF | Visualizar/Abrir |
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