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Bone morphogenetic protein 15 and growth differentiation factor 9 in European sea bass oocyte development

AuthorsGarcía-López, Ángel ; Halm, Silke ; Tyler, Charles R.; Martínez-Rodríguez, Gonzalo ; Prat, Francisco
Issue DateJul-2010
Citation9th International Congress on the Biology of Fish (2010)
AbstractIt is well known that vertebrate oocytes contribute actively to follicle development and maturation by secreting a variety of growth factors, among which growth differentiation factor 9 (GDF9/gdf9) and bone morphogenetic factor 15 (BMP15/bmp15) have been paid particular attention both in mammals and in zebrafish. Recently, we have cloned the cDNA sequences encoding for gdf9 and bmp15 in the European sea bass Dicentrarchus labrax, the most important commercial marine fish species in the Mediterranean area, and reported their high mRNA levels in early stages of ovarian development. Here, we provide further evidences supporting the potential roles of gdf9 and bmp15 in sea bass folliculogenesis. Specific antibodies were raised and used to quantify protein levels throughout oocyte development as well as for cellular localization studies together with in situ hybridization approaches. In addition, the roles of both factors on the compensatory ovarian growth induced by unilateral ovariectomy were evaluated.
DescriptionTrabajo presentado en el 9th International Congress on the Biology of Fish, celebrado en Barcelona del 5 al 9 de julio de 2010.
Appears in Collections:(ICMAN) Comunicaciones congresos
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