English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/109889
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA

AuthorsMárquez, Ana; Solans, Roser; Hernández-Rodríguez, José; Cid, María C.; Castañeda, S.; Ramentol, Marc; Rodríguez-Rodríguez, Luis; Narváez, J.; Blanco, Ricardo; Ortego-Centeno, N.; Palm, Øyvind; Diamantopoulos, Andreas P.; Braun, N.; Moosig, Frank; Witte, Torsten; Beretta, Lorenzo; Lunardi, C.; Cimmino, Augusto Vaglio; Salvarani, Carlo; González-Gay, M. A.; Martín, J.
Issue Date2014
PublisherPublic Library of Science
CitationPLoS ONE 9 (2014)
Abstract© 2014 Márquez et al. Introduction: Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on GCA predisposition. Methods: A total of 1,363 biopsy-proven GCA patients and 3,908 healthy controls from four European cohorts (Spain, Italy, Germany and Norway) were combined in a meta-analysis. Six genetic variants: rs3939286, rs7025417 and rs7044343, within the IL33 gene, and rs2058660, rs2310173 and rs13015714, within the IL1RL1 gene, previously associated with immunerelated diseases, were genotyped using predesigned TaqMan assays. Results: A consistent association between the rs7025417 polymorphism and GCA was evident in the overall meta-analysis, under both allele (PMH = 0.041, OR = 0.88, CI 95% 0.78-0.99) and recessive (PMH = 3.40E-03, OR = 0.53, CI 95% 0.35-0.80) models. No statistically significant differences between allele or genotype frequencies for the other IL33 and IL1RL1 genetic variants were detected in this pooled analysis. Conclusions: Our results clearly evidenced the implication of the IL33 rs7025417 polymorphism in the genetic network underlying GCA.
Identifiersdoi: 10.1371/journal.pone.0113476
issn: 1932-6203
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
A_Candidate_Gene.pdf313,69 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.