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Exposure to human pharmaceuticals produces differential transcriptome expression fingerprints in the brain of the sea bream, Sparus aurata

AuthorsHampel, Miriam ; Milan, Massimo; Blasco, Julián ; Ferraresso, Serena; Bargelloni, Luca
Issue DateNov-2013
Citation4th SCARCE International Conference (2013)
AbstractPharmaceuticals are pseudo pe rsistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Gilthead seab ream (Sparus aurata) were exposed to Acetaminophen (APAP): 31.90 ± 11.07; Atenolol (AT): 0.95 ± 0.38 and Carbamazepine (CBZ): 6.95 ± 0.13 μg•L-1 for 28 days to (1) determine whether exposure to environmentally rele vant concentrations of the pharmaceuticals alters the brain transcripome; and (2) identify different expression profiles and treatment specific modes of action and pathways. After APAP, AT and CBZ treatment, 411, 7 and 612 differently expressed transcripts were identified, respectively. Out of these, 248 features were common between APAP and CBZ and one between CBZ and AT. Two features were common across all treatments.
DescriptionTrabajo presentado en la 4th SCARCE International Conference (Towards a better understanding of the links between stressors, hazard assessment and ecosystem services under water scarcity), celebrada en Cádiz el 25 y 26 de noviembre de 2013.
Appears in Collections:(ICMAN) Comunicaciones congresos
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