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Título

Induction of H3.3 replacement histone mRNAs during the precommitment period of murine erythroleukemia cell differentiation

Autor Krimer, Dora B. ; Cheng, Genhong; Skoultchi, Arthur I.
Fecha de publicación 1993
EditorOxford University Press
Citación Nucleic Acids Research, 1993, 21 (12) 2873-2879
ResumenDifferential hybridization to a cDNA library made from the mRNA of differentiating mouse erythroleukemia (MEL) cells has been used to identify sequences that are induced during the early stages of MEL cell differentiation. One of the differentially expressed genes identified encodes the H3.3 histone subtype. We show here that the three polyadenylated mRNAs produced from the H3.3B gene, as well as the single mRNA produced from the related H3.3A gene, are coordinately induced during the first few hours of MEL cell differentiation and subsequently down regulated as cells undergo terminal differentiation. Nuclear runon transcription experiments indicate that the accumulation and decay of these mRNAs are controlled at the post-transcriptional level. Unlike the polyadenylated mRNAs of two Hi histone genes that exhibit similar kinetics of induction and decay controlled by c-myc, induction of the H3.3 mRNAs is unaffected by deregulated expression of c-myc.
Descripción 7 p.-8 fig.
Versión del editorhttp://nar.oxfordjournals.org/content/21/12/2873.abstract
URI http://hdl.handle.net/10261/109832
ISSN0305-1048
E-ISSN1362-4962
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