English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/109645
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

An integrated device for magnetically-driven drug release and in situ quantitative measurements: Design, fabrication and testing

AuthorsBruvera, I. J.; Hernández, R.; Mijangos, Carmen ; Goya, G. F.
KeywordsHydrogels
Magnetic hyperthermia
Magnetic nanoparticles
Drug release
Issue Date2015
PublisherElsevier
CitationJournal of Magnetism and Magnetic Materials 377: 446-451 (2015)
AbstractWe have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) × 10-9 g, demonstrating the potential of this device for very precise quantitative control of drug release.
URIhttp://hdl.handle.net/10261/109645
DOI10.1016/j.jmmm.2014.10.149
Identifiersdoi: 10.1016/j.jmmm.2014.10.149
issn: 0304-8853
Appears in Collections:(ICTP) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.