English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/109356
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

DNA replication fading as proliferating cells advance in their commitment to terminal differentiation

AuthorsMonturus, Estefanía; Ganier, Olivier; Hernandez, Pablo ; Schvartzman, Jorge Bernardo ; Mechali, Marcel; Krimer, Dora B.
Issue Date20-Feb-2012
PublisherNature Publishing Group
CitationScientific Reports 2: 279 (2012)
AbstractTerminal differentiation is the process by which cycling cells stop proliferating to start new specific functions. It involves dramatic changes in chromatin organization as well as gene expression. In the present report we used cell flow cytometry and genome wide DNA combing to investigate DNA replication during murine erythroleukemia-induced terminal cell differentiation. The results obtained indicated that the rate of replication fork movement slows down and the inter-origin distance becomes shorter during the precommitment and commitment periods before cells stop proliferating and accumulate in G1. We propose this is a general feature caused by the progressive heterochromatinization that characterizes terminal cell differentiation.
Description8 p.-4 fig.
Publisher version (URL)http://dx.doi.org/10.1038/srep00279
URIhttp://hdl.handle.net/10261/109356
DOI10.1038/srep00279
ISSN2045-2322
E-ISSN2045-2322
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
Scientific Reports, 2012. D.B. Krimer.pdf603,88 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.