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Title

Tick-bite-induced anaphylaxis in Spain

AuthorsFernández Soto, Pedro; Dávila, I.; Laffond, E.; Lorente, F.; Encinas Grandes, Antonio; Pérez Sánchez, Ricardo
Issue DateJan-2001
PublisherRoutledge
CitationAnnals of Tropical Medicine and Parasitology 95(1): 97-103 (2001)
AbstractAlthough there are very few reports of human anaphylaxis induced by tick bites, two such cases have recently been seen in Salamanca, Spain. To identify the tick species responsible, salivary-gland extracts from six species of hard tick and two of soft tick were prepared and used as allergens/antigens in skin-prick tests and serological analyses. For each case, the results of the skin tests were positive for several species of hard tick but negative for the soft ticks. ELISA and western blots revealed high titres of IgG against hard ticks (but not soft ticks) in the sera from both cases. However, serum from only one of the cases was found to be ELISA- and western-blot-positive for tick-specific IgE. Accordingly, the anaphylaxis seen in one case was IgE-mediated whereas that in the other case appeared to be IgE-independent. In both cases, most of the tick-specific antibodies only recognized carbohydrate epitopes. High levels of cross-reactivity between the salivary-gland extracts from several species of hard tick made it impossible to identify which species was responsible for each anaphylactic reaction, although the immunolgical results seem to point to Ixodes ricinus.
Description7 pages, 2 figures.-- PMID: 11235559 [PubMed].
Publisher version (URL)http://www.ingentaconnect.com/content/routledg/catm/2001/00000095/00000001/art00011?token=004810966720297d76253e7b3a4a45242442422c496d3f6a4b6e4e395e4e6b63314fe220
URIhttp://hdl.handle.net/10261/10917
ISSN0003-4983
Appears in Collections:(IRNASA) Artículos
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