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RightsPreviewIssue DateTitleAuthor(s)Type
1closedAccessJul-2010Laforin, the most common protein mutated in Lafora disease, regulates autophagyAguado, Carmen; Criado-García, Olga ; Vernia, Santiago ; Boya, Patricia ; Sanz, Pascual  ; Rodríguez de Córdoba, Santiago ; Knecht, Erwin; Rubinsztein, David C.artículo
2openAccess1471-2148-11-225-S6.TIFF.jpg28-Jul-2011Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional levelRomá-Mateo, Carlos ; Moreno, Daniel; Vernia, Santiago ; Rubio, Teresa ; Bridges, Travis M; Gentry, Matthew S; Sanz, Pascual  artículo
3openAccessPlos One 006-e24040.pdf.jpg26-Aug-2011Laforin, a dual specificity phosphatase involved in lafora disease, is present mainly as monomeric form with full phosphatase activityDukhande, Vikas V.; Rogers, Devin M.; Romá-Mateo, Carlos ; Donderis, Jorge ; Marina, Alberto  ; Taylor, Adam O.; Sanz, Pascual  ; Gentry, Matthew S.artículo
4closedAccessrestringido.pdf.jpg1-Oct-2010Impaired autophagy in Lafora diseaseKnecht, Erwin; Aguado, Carmen; Sarkar, Sovan; Korolchuk, Viktor I.; Criado-García, Olga ; Vernia, Santiago ; Boya, Patricia ; Sanz, Pascual  ; Rodríguez de Córdoba, Santiago ; Rubinsztein, David C.artículo
5closedAccessAug-2005Structure—function analysis of the α5 and the α13 helices of human glucokinase: Description of two novel activating mutationsPedelini, Leda ; García-Gimeno, María Adelaida ; Marina, Alberto  ; Gomez-Zumaquero, Juan M.; Rodriguez-Bada, Pablo; López-Enriquez, Soledad; Soriguer, Federico C.; Cuesta-Muñoz, Antonio L.; Sanz, Pascual  artículo
6closedAccessSep-2002Convergence of the TOR and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE regulated genesMayordomo, Isabel; Estruch, Francisco; Sanz, Pascual  artículo
7closedAccessaccesoRestringido.pdf.jpg1-Jul-2011Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice.Vernia, Santiago ; Heredia, Miguel ; Criado-García, Olga ; Rodríguez de Córdoba, Santiago ; Sanz, Pascual  artículo
8openAccessPlos One 2011.pdf.jpg30-Jun-2011A PTG Variant Contributes to a Milder Phenotype in Lafora DiseaseGuerrero, Rosa; Vernia, Santiago ; Sanz, Raúl; Abreu-Rodríguez, Irene; Almaraz, Carmen; García-Hoyos, María; Michelucci, Roberto; Tassinari, Carlo Alberto; Riguzzi, Patrizia; Nobile, Carlo; Sanz, Pascual  ; Serratosa, José M.; Gómez-Garre, Pilarartículo
9openAccessglycogen_synthesis_Solaz.pdf.jpg1-Mar-2008Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathwaySolaz-Fuster, Maria Carmen ; Gimeno-Alcañiz, José Vicente; Ros, Susana; Fernández-Sánchez, Maria Elena; García-Fojeda, Belén; Criado-García, Olga ; Vilchez, David; Domínguez, Jorge; Ros, Susana; García-Rocha, Mar; Sánchez-Piris, Maribel; Aguado, Carmen; Knecht, Erwin; Serratosa, José María; Sanz, Pascual  ; Rodríguez de Córdoba, Santiago artículo
10openAccesslafora_disease_Roma.pdf.jpg1-Nov-2011Laforin, a dual specificity protein phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinaseRomá-Mateo, Carlos ; Solaz-Fuster, Maria Carmen ; Gimeno-Alcañiz, José Vicente; Donderis, Jorge ; Marina, Alberto  ; Criado-García, Olga ; Rodríguez de Córdoba, Santiago ; Sanz, Pascual  artículo
11openAccessPLoS ONE 004-e05907.pdf.jpg16-Jun-2009Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforinVernia, Santiago ; Rubio, Teresa ; Heredia, Miguel ; Rodríguez de Córdoba, Santiago ; Sanz, Pascual  artículo
12openAccessMol Biol Cell 021-02578 2010.pdf.jpg9-Jun-2010The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β SubunitsMoreno Andrés, Daniel ; Towler, Mhairi; Hardie, D. Grahame; Knecht, Erwin; Sanz, Pascual  artículo
13openAccesspicrender.pdf.jpg2-Apr-2007A conserved sequence immediatelly N-terminal to the bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunitsViana, Rosa  ; Towler, Mhairi; Pan, David A.; Carling, David; Viollet, Benoit; Hardie, D. Grahame; Sanz, Pascual  artículo
14openAccess2111495_B1.pdf.jpg1-Nov-1998Cepa de levadura de panadería CECT10868 y cepa de panadería CECT10869. Su método de obtención por técnicas de ADN recombinante y su aplicación como levaduras de panaderíaSanz, Pascual  ; Prieto Alamán, José Antonio ; Pérez-González, José A.; Ramón, Daniel ; Monfort Roig, Aureliapatente
15closedAccessaccesoRestringido.pdf.jpg2003Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulationFernández-Sánchez, Maria Elena; Criado-García, Olga ; Heath, Karen E.; García-Fojeda, Belén; Medraño-Fernández, Iria; Gómez-Garre, Pilar; Sanz, Pascual  ; Serratosa, José María; Rodríguez de Córdoba, Santiago artículo
16openAccessFEBS J first version.pdf.jpg16-Mar-2012Laforin, a protein with many faces: glucan phosphatase, adapter protein, et aliiGentry, Matthew S.; Romá-Mateo, Carlos ; Sanz, Pascual  preprint
17openAccess2012 FEBS Lett 586-4241.pdf.jpg29-Oct-2012Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathwayGarcía-Haro, Luisa ; García-Gimeno, María Adelaida ; Neumann, Dietbert; Beullens, Monique; Bollen, Mathieu; Sanz, Pascual  artículo
18openAccess2013 Plos One 008-e69523.pdf.jpg26-Jul-2013Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329Sánchez-Martín, Pablo; Raththagala, Madushi; Bridges, Travis M.; Husodo, Satrio; Gentry, Matthew S.; Sanz, Pascual  ; Romá-Mateo, Carlos artículo
19openAccessprotein_kinase_Vernia.pdf.jpg27-Mar-2009AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-PP1 holoenzyme and accelerates its downregulation by the laforin-malin complexVernia, Santiago ; Solaz-Fuster, Maria Carmen ; Gimeno-Alcañiz, José Vicente; Rubio, Teresa ; García-Haro, Luisa ; Foretz, Marc; Rodríguez de Córdoba, Santiago ; Sanz, Pascual  artículo
20openAccess12858_2015_Article_53.pdf.jpg23-Oct-2015The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2Viana, Rosa  ; Luján, Pablo; Sanz, Pascual  artículo
21openAccess2013 Int. J. Biochem Cell Biol 45-1479.pdf.jpg26-Apr-2013Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complexRubio-Villena, Carla ; García-Gimeno, María Adelaida ; Sanz, Pascual  artículo
22openAccesshistone_carbonylation_Garcia.pdf.jpg15-Apr-2012Histone carbonylation occurs in proliferating cellsGarcía-Giménez, José Luis; Velázquez Ledesma, Ana María; Esmoris, Isabel; Romá-Mateo, Carlos ; Sanz, Pascual  ; Viña, José; Pallardó, Federico V.artículo
23openAccess2013 Mol Biol Cell 24-1801.pdf.jpg3-Apr-2013Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activityRubio, Teresa ; Vernia, Santiago ; Sanz, Pascual  artículo
24openAccess2008 J. Hum Genet 53-460.pdf.jpg6-Mar-2008Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity onset diabetes of the young (MODY2) patientsEstalella, Itziar; García-Gimeno, María Adelaida ; Marina, Alberto  ; Castaño, Luis; Sanz, Pascual  artículo
25openAccess2015 Plos One 010-e0131476.pdf.jpg26-Jun-2015Structure-Function Analysis of PPP1R3D, a Protein Phosphatase 1 Targeting Subunit, Reveals a Binding Motif for 14-3-3 Proteins which Regulates its Glycogenic PropertiesRubio-Villena, Carla ; Sanz, Pascual  ; García-Gimeno, María Adelaida artículo
26openAccessRoma Mateo 2015 Mol Neurobiol.pdf.jpg17-May-2014Increased oxidative stress and impaired antioxidant response in Lafora diseaseRomá-Mateo, Carlos ; Aguado, Carmen; García-Giménez, José Luis; Ibáñez-Cabellos, José Santiago; Seco-Cervera, Marta; Pallardó, Federico V.; Knecht, Erwin; Sanz, Pascual  artículo
27openAccessRoma Mateo 2015 FRBM.pdf.jpg10-Feb-2015Oxidative stress, a new hallmark in the pathophysiology of Lafora progressive myoclonus epilepsyRomá-Mateo, Carlos ; Aguado, Carmen; García-Giménez, José Luis; Knecht, Erwin; Sanz, Pascual  ; Pallardó, Federico V.artículo
28openAccessGarcia-Gimenez et al Manuscript 2012 REVISION.pdf.jpg9-Jul-2013Lafora disease fibroblasts exemplify the molecular interdependence between thioredoxin 1 and the proteasome in mammalian cellsGarcía-Giménez, José Luis; Seco-Cervera, Marta; Aguado, Carmen; Dasí, Francisco; Romá-Mateo, Carlos ; Priego, Sonia; Markovic, Jelena; Knecht, Erwin; Sanz, Pascual  ; Pallardó, Federico V.artículo
29openAccess2016 PLoS ONE 011-e0163898.pdf.jpg3-Oct-2016Studying Closed Hydrodynamic Models of "In Vivo" DNA Perfusion in Pig Liver for Gene Therapy Translation to Humans.Sendra, Luis; Miguel, Antonio; Pérez-Enguix, Daniel; Herrero, María José ; Montalvá, Eva; García-Gimeno, María Adelaida ; Noguera, Inmaculada; Díaz, Ana; Pérez, Judith; Sanz, Pascual  ; López-Andújar, Rafael; Martí-Bonmatí, Luis; Aliño, Salvador F.artículo
30openAccess2018 FEBS J 285-2071 Author Copy.pdf.jpgJun-2018Degradation of altered mitochondria by autophagy is impaired in Lafora diseaseLahuerta, Marcos; Aguado, Carmen; Sánchez-Martín, Pablo; Sanz, Pascual  ; Knecht, Erwinartículo
31openAccessUS2017283378A1.pdf.jpg5-Oct-2017Indole derivatives for the prevention and/or treatment of diabetes and associated metabolic disordersCastro, Ana ; Sanz, Pascual  ; Vela Ruiz, Marta; García Gimeno, María Adelaidasolicitud de patente
32openAccess2018 Hum Mol Genet 27-1290 vers aut.pdf.jpg1-Apr-2018Astrocytes: new players in progressive myoclonus epilepsy of Lafora typeRubio-Villena, Carla ; Viana, Rosa  ; Bonet, Jose; Garcia-Gimeno, Maria Adelaida; Casado, Marta  ; Heredia, Miguel ; Sanz, Pascual  artículo
33openAccessWO2017098073A1.pdf.jpg15-Jun-2017Spiranic derivative compounds of oxindole-pirazolo[3,4-b]pyridinone and therapeutic uses thereofCastro, Ana ; Sanz, Pascual  ; Quesada Sánchez, Sergio; García Gimeno, María Adelaida; Luque Garriga, Francisco Javier; Bidon-Chanal Badia, Axelsolicitud de patente
34openAccessAuthor copy MiMB 2018.pdf.jpg12-Apr-2018AMPK Protein Interaction Analyses by Yeast Two-HybridSanz, Pascual  ; Viana, Rosa  ; Garcia-Gimeno, Maria Adelaidaartículo
35openAccessEP3196190A1.pdf.jpg26-Jul-2017Indole derivatives for the prevention and/or treatment of diabetes and associated metabolic disordersCastro, Ana ; Sanz, Pascual  ; Vela Ruiz, Marta; García Gimeno, María Adelaidasolicitud de patente
36openAccess2008 Curr Protein Pept Sci 9-478.pdf.jpgOct-2008AMP-activated protein kinase: structure and regulation.Sanz, Pascual  artículo
37closedAccessaccesoRestringido.pdf.jpg2003New mutations of Saccharomyces cerevisiae that partially relieve both glucose and galactose repression activate the protein kinase Snf1Rodríguez, Cristina ; Sanz, Pascual  ; Gancedo, Carlos artículo
38openAccess2008 BBRC 369-964.pdf.jpg9-May-2008Role of AMP-activated protein kinase in autophagy and proteasome functionViana, Rosa  ; Aguado, Carmen; Esteban, Inmaculada; Moreno, Daniel; Viollet, Benoit; Knecht, Erwin; Sanz, Pascual  artículo
39openAccess2009 Mol Endocrinol 23-1983.pdf.jpg2-Nov-2009Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) geneBarbetti, Fabrizio; Cobo-Vuilleumier, Nadia ; Toni, Sonia; Dionisi-Vici, Carlo; Ciampalini, Paolo; Massa, Ornella; Rodriguez-Bada, Pablo; Colombo, Carlo; Lenzi, Lorenzo; García-Gimeno, María Adelaida ; Bermúdez-Silva, Francisco Javier; Rodriguez de Fonseca, Fernando; Banin, Patrizia; Aledo, Juan C.; Baixeras, Elena; Sanz, Pascual  ; Cuesta-Muñoz, Antonio L.artículo
40openAccess2011 J Mol Med 89-915.pdf.jpg20-Apr-2011Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolismCouarch, Philippe; Vernia, Santiago ; Gourfinkel-An, Isabelle; Lesca, Gaëtan; Gataullina, Svetlana; Fedirko, Estelle; Trouillard, Oriane; Depienne, Christel; Dulac, Olivier; Steschenko, Dominique; Leguern, Eric; Sanz, Pascual  ; Baulac, Stéphanieartículo
41openAccess2012 JBC 287-1306.pdf.jpg28-Nov-2011Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survivalFréville, Aline; Landrieu, Isabelle; García-Gimeno, María Adelaida ; Kalamou, Hadidjatou; Montbarbon, Muriel; Bertin, Benjamin; Sanz, Pascual  ; Werkmeister, Elisabeth; Pierrot, Christine; Khalife, Jamalartículo
42openAccess2012 IUBMB life 64-801.pdf.jpg20-Jul-2012Deciphering the role of malin in the Lafora progressive myoclonus epilepsyRomá-Mateo, Carlos ; Sanz, Pascual  ; Gentry, Matthew S.artículo
43openAccess2013 FEBS J 280-3723.pdf.jpg24-Jun-2013AMPKbeta subunits, more than just a scaffold in the formation of AMPK complexSanz, Pascual  ; Rubio, Teresa ; García-Gimeno, María Adelaida artículo
44openAccess2009 Int. J. Biochem Cell Biol 41-2341.pdf.jpgDec-2009Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinaseMoreno, Daniel; Viana, Rosa  ; Sanz, Pascual  artículo
45openAccess2009 Horm Metab Res 41-320.pdf.jpgApr-2009Diagnostic difficulties in glucokinase hyperinsulinismMeissner, T.; Marquard, J.; Cobo-Vuilleumier, Nadia ; Maringa, M.; Rodríguez-Bada, P.; García-Gimeno, María Adelaida ; Castro, M. J.; Aledo, J. C.; Baixeras, Elena; Weber, J.; Olek, K.; Sanz, Pascual  ; Mayatepek, E.; Cuesta-Muñoz, Antonio L.artículo
46openAccess2008 Biochem J 415-233.pdf.jpg15-Oct-2008Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cellRiera, Alberto; Ahuatzi, Deifilia; Herrero, Pilar ; García-Gimeno, María Adelaida ; Sanz, Pascual  ; Moreno, Fernando artículo
47openAccess2008 FEBS Letters 582-2650.pdf.jpg23-Jul-2008A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanismMoreno, Daniel; Knecht, Erwin; Viollet, Benoit; Sanz, Pascual  artículo
48openAccess2012_Knecht et al_Autophagy.pdf.jpg1-Apr-2012Malin knockout mice support a primary role of autophagy in the pathogenesis of Lafora diseaseKnecht, Erwin; Criado-García, Olga ; Gayarre, Javier; Durán-Trío, Lara ; Vernia, Santiago ; Heredia, Miguel ; Romá-Mateo, Carlos ; Mourón, Silvana; Juana-López, Lucía ; Sanz, Pascual  ; Bovolenta, Paola ; Rodríguez de Córdoba, Santiago artículo
49closedAccessaccesoRestringido.pdf.jpg2012Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagyCriado-García, Olga ; Gayarre, Javier; Durán-Trío, Lara ; Vernia, Santiago ; Heredia, Miguel ; Romá-Mateo, Carlos ; Mourón, Silvana; Juana-López, Lucía ; Sanz, Pascual  ; Bovolenta, Paola ; Rodríguez de Córdoba, Santiago artículo
50openAccess2017 EMBO J 36-1946 Vers Aut.pdf.jpg3-Jul-2017AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.Theret, Marine; Gsaier, Linda; Schaffer, Bethany; Juban, Gaëtan; Ben Larbi, Sabrina; Weiss-Gayet, Michèle; Bultot, Laurent; Collodet, Caterina; Foretz, Marc; Desplanches, Dominique; Sanz, Pascual  ; Zang, Zizhao; Yang, Lin; Vial, Guillaume; Viollet, Benoit; Sakamoto, Kei; Brunet, Anne; Chazaud, Bénédicte; Mounier, Rémiartículo
Results 1-50 of 73 (Search time: 2.851 seconds).