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dc.contributor.author | García-Álvarez, Isabel | - |
dc.contributor.author | Garrido, Leoncio | - |
dc.contributor.author | Romero-Ramírez, Lorenzo | - |
dc.contributor.author | Nieto-Sampedro, Manuel | - |
dc.contributor.author | Fernández-Mayoralas, Alfonso | - |
dc.contributor.author | Campos-Olivas, Ramón | - |
dc.date.accessioned | 2014-12-10T09:56:32Z | - |
dc.date.available | 2014-12-10T09:56:32Z | - |
dc.date.issued | 2013 | - |
dc.identifier | doi: 10.1371/journal.pone.0078391 | - |
dc.identifier | issn: 1932-6203 | - |
dc.identifier | e-issn: 1932-6203 | - |
dc.identifier.citation | PLoS ONE 8 (10): e78391 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/108571 | - |
dc.description.abstract | The effect of the treatment with glycolipid derivatives on the metabolic profile of intact glioma cells and tumor tissues, investigated using proton high resolution magic angle spinning (1H HR-MAS) nuclear magnetic resonance (NMR) spectroscopy, is reported here. Two compounds were used, a glycoside and its thioglycoside analogue, both showing anti-proliferative activity on glioma C6 cell cultures; however, only the thioglycoside exhibited antitumor activity in vivo. At the drug concentrations showing anti-proliferative activity in cell culture (20 and 40 μM), significant increases in choline containing metabolites were observed in the 1H NMR spectra of the same intact cells. In vivo experiments in nude mice bearing tumors derived from implanted C6 glioma cells, showed that reduction of tumor volume was associated with significant changes in the metabolic profile of the same intact tumor tissues; and were similar to those observed in cell culture. Specifically, the activity of the compounds is mainly associated with an increase in choline and phosphocholine, in both the cell cultures and tumoral tissues. Taurine, a metabolite that has been considered a biomarker of apoptosis, correlated with the reduction of tumor volume. Thus, the results indicate that the mode of action of the glycoside involves, at least in part, alteration of phospholipid metabolism, resulting in cell death. | - |
dc.description.sponsorship | The financial support was provided by the Servicio de Salud de Castilla-La Mancha Community (SESCAM), Fundación para la Investigación Sanitaria de Castilla-La Mancha (FISCAM) (PI-2008/18, PI-2008/19 and PI-2009/51); Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS) (PI11/00592 and PI11/01436) and Comunidad de Madrid (Grant S2009/PPQ-1752). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | - |
dc.publisher | Public Library of Science | - |
dc.rights | openAccess | - |
dc.title | The Effect of Antitumor Glycosides on Glioma Cells and Tissues as Studied by Proton HR-MAS NMR Spectroscopy | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1371/journal.pone.0078391 | - |
dc.date.updated | 2014-12-10T09:56:32Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.identifier.pmid | 24194925 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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