English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/108544
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 5 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Surface hierarchical porosity in poly (¿-caprolactone) membranes with potential applications in tissue engineering prepared by foaming in supercritical carbon dioxide

Autor Pintado-Sierra, Mercedes ; Delgado, Luis; Aranaz, Inmaculada ; Marcos-Fernández, Ángel ; Reinecke, Helmut ; Gallardo Ruiz, Alberto ; Zeugolis, Dimitrios; Elvira, Carlos
Palabras clave Membranes
Tissue engineering
Porous materials
Surface hierarchical porosity
Supercritical carbon dioxide
Poly (ε-caprolactone)
Fecha de publicación 2014
EditorElsevier
Citación Journal of Supercritical Fluids 95: 273-284 (2014)
ResumenThis article describes the preparation of porous poly (¿-caprolactone), PCL, membranes by supercritical CO2 (SCCO2) foaming, displaying surface hierarchical macroporosity which could be tailored by careful control of the pressure, in the range of 150¿250 bar, and depressurization processes in several steps, showing also pore interconnectivity between both membrane faces. The membranes exhibited two distinct types of surface macroporosity, the larger with diameter sizes of 300¿500 ¿m were surrounded by and also composed of smaller pores of 15¿50 ¿m (same size as inner pores). Membranes were prepared by solvent casting and submitted to different SCCO2 foaming. Parameters such as membrane thickness, CO2 flow, foaming time, pressure, temperature and the depressurization processes (rate and profiles), were varied to determine their influence on final porosity and to decipher which parameters were the most critical ones in terms of surface hierarchical pore organization. No remarkable changes in PCL crystallinity were found when membranes were processed under SCCO2. Finally, biological evaluation of the porous membranes was achieved by seeding human skin fibroblasts on the prepared membranes. The results, in terms of cell adhesion, spreading, proliferation and metabolic activity indicate that these membranes could hold promise for the fabrication of meshes with controlled porosity for tissue engineering applications.
URI http://hdl.handle.net/10261/108544
DOI10.1016/j.supflu.2014.09.019
Identificadoresdoi: 10.1016/j.supflu.2014.09.019
issn: 0896-8446
e-issn: 1872-8162
Aparece en las colecciones: (IQOG) Artículos
(ICTP) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.