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Synthesis and antiproliferative activity of 6-phenylaminopurines

AuthorsCanela, María-Dolores ; Liekens, S.; Camarasa Rius, María José ; Priego, Eva María ; Peréz-Pérez, María-Jesús
KeywordsAntiproliferative agents
Cell cycle analysis
Microwave-assisted synthesis
Issue Date2014
CitationEuropean Journal of Medicinal Chemistry 87: 421-428 (2014)
AbstractA series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring different groups at positions 2, 8 and 9 of the purine ring and at the exocyclic nitrogen atom at position 6. Among the newly described purines, five compounds showed antiproliferative activity with IC50 values below 10 μM, the tetrahydroquinoline derivative at position 6 of phenylaminopurine being the most active of the series in the six cell lines tested. Moreover, the compounds induced G2/M phase arrest inhuman cervical carcinoma HeLa cells as reported for tubulin depolymerizing agents.
Publisher version (URL)http://dx.doi.org/10.1016/j.ejmech.2014.09.093
Identifiersdoi: 10.1016/j.ejmech.2014.09.093
issn: 0223-5234
e-issn: 1768-3254
Appears in Collections:(IQM) Artículos
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