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Título: | Synthesis and antiproliferative activity of 6-phenylaminopurines |
Autor: | Canela, María-Dolores CSIC; Liekens, S.; Camarasa Rius, María José CSIC ORCID; Priego, Eva María CSIC ORCID; Peréz-Pérez, María-Jesús CSIC ORCID | Palabras clave: | Antiproliferative agents Cell cycle analysis Microwave-assisted synthesis Purines |
Fecha de publicación: | 2014 | Citación: | European Journal of Medicinal Chemistry 87: 421-428 (2014) | Resumen: | A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring different groups at positions 2, 8 and 9 of the purine ring and at the exocyclic nitrogen atom at position 6. Among the newly described purines, five compounds showed antiproliferative activity with IC50 values below 10 μM, the tetrahydroquinoline derivative at position 6 of phenylaminopurine being the most active of the series in the six cell lines tested. Moreover, the compounds induced G2/M phase arrest inhuman cervical carcinoma HeLa cells as reported for tubulin depolymerizing agents. | Versión del editor: | http://dx.doi.org/10.1016/j.ejmech.2014.09.093 | URI: | http://hdl.handle.net/10261/107974 | DOI: | 10.1016/j.ejmech.2014.09.093 | Identificadores: | doi: 10.1016/j.ejmech.2014.09.093 issn: 0223-5234 e-issn: 1768-3254 |
Aparece en las colecciones: | (IQM) Artículos |
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