English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/10732
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Protein co-evolution, co-adaptation and interactions

AuthorsPazos, Florencio; Valencia, Alfonso
KeywordsCo-evolution
Protein–protein interaction
Interactome
Phylogenetic tree
Issue Date25-Sep-2008
PublisherNature Publishing Group
CitationThe EMBO Journal 2008, 27 (20): 2648–2655
AbstractCo-evolution has an important function in the evolution of species and it is clearly manifested in certain scenarios such as host–parasite and predator–prey interactions, symbiosis and mutualism. The extrapolation of the concepts and methodologies developed for the study of species co-evolution at the molecular level has prompted the development of a variety of computational methods able to predict protein interactions through the characteristics of co-evolution. Particularly successful have been those methods that predict interactions at the genomic level based on the detection of pairs of protein families with similar evolutionary histories (similarity of phylogenetic trees: mirrortree). Future advances in this field will require a better understanding of the molecular basis of the co-evolution of protein families. Thus, it will be important to decipher the molecularmechanisms underlying the similarity observed in phylogenetic trees of interacting proteins, distinguishing direct specific molecular interactions from other general functional constraints. In particular, it will be important to separate the effects of physical interactions within protein complexes (‘co-adaptation’) from other forces that, in a less specific way, can also create general patterns of co-evolution.
DescriptionIncluye una figura.
Publisher version (URL)http://dx.doi.org/doi:10.1038/emboj.2008.189
URIhttp://hdl.handle.net/10261/10732
DOI10.1038/emboj.2008.189
ISSN0261-4189
E-ISSN1460-2075
Appears in Collections:(CNB) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.