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Título

Synergistic effect between different milk-derived peptides and proteins

AutorLópez-Expósito, Iván ; Pellegrini, A.; Amigo, Lourdes ; Recio, Isidra
Palabras claveSynergism
Milk-derived antibacterial peptide
Antibacterial milk protein
Fecha de publicaciónjun-2008
EditorAmerican Dairy Science Association
CitaciónJournal of Dairy Science 91(6): 2184-2189 (2008)
ResumenAntimicrobial peptides derived from food proteins constitute a new field in the combined use of antimicrobial agents in food. The best examples of milk-derived peptides are those constituted by bovine lactoferricin [lactoferrin f(17–41)] (LFcin-B) and bovine α(s2)-casein f(183–207). The aim of this work was to study if the antimicrobial activity of a natural compound employed in food preservation, nisin, could be enhanced by combination with the aforementioned milk-derived peptides. Furthermore, the possibility of a synergistic effect between these peptides and bovine lactoferrin (LF) against Escherichia coli and Staphylococcus epidermidis was also studied. Finally, the most active combinations were assayed against the foodborne pathogens Listeria monocytogenes and Salmonella choleraesuis. Results showed a synergistic effect when LFcin-B was combined with bovine LF against E. coli. In the same way, the combination of LFcin-B with bovine LF was synergistic against Staph. epidermidis. Bovine LF and nisin increased their antimicrobial activity when they were assayed together with bovine α(s2)-casein f(183–207). It is important to note the synergistic effect among LFcin-B and bovine LF, because both compounds might be simultaneously in the suckling gastrointestinal tract and could, therefore, have a protective effect on it. The other synergistic effect high-lighted is that between α(s2)-casein f(183–207) and nisin against L. monocytogenes because of the ability of L. monocytogenes to develop resistance to nisin.
Descripción6 pages, 1 figure.-- PMID: 18487640 [PubMed].
Versión del editorhttp://dx.doi.org/10.3168/jds.2007-0037
URIhttp://hdl.handle.net/10261/10667
DOI10.3168/jds.2007-0037
ISSN0022-0302
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