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Título

Mass spectrometry for identifying pharmaceutical biotransformation products in the environment

AutorKosjek, T.; Heath, E.; Petrovic, Mira; Barceló, Damià
Palabras claveBiodegradation
Environmental sample
Gas chromatography
Hyphenated technique
Identification
Liquid chromatography
Mass spectrometry
Metabolite
Pharmaceuticals
Fecha de publicación26-oct-2007
EditorElsevier
CitaciónTrAC-Trends in Analytical Chemistry 26(11): 1076-1085 (2007)
ResumenMany classes of pharmaceuticals have been detected in wastewaters and surface waters around Europe, but little is known about their occurrence, fate and potential harmful effects on the environment, and that makes them an important group among those compounds considered to be new emerging contaminants. To understand the cycling of pharmaceuticals and their metabolites, it is essential to possess qualitative and quantitative information on their presence in the environment. This review covers the current status and future prospects of advanced hyphenated mass spectrometric (MS) techniques (gas chromatography-MS (GC-MS) and liquid chromatography-MS (LC-MS)) in elucidating the structures of trace contaminants, namely pharmaceutical biodegradation products in complex environmental matrices. The article is oriented towards technique and method and discusses capabilities, potential and limitations of different GC and LC mass analyzers (quadrupole, ion trap, time-of-flight and hybrid techniques) in dealing with analytical challenges of complex matrices and trace contaminants. We also give practical examples of their applications. The main scope of this article is to support and to facilitate the on-going research on pharmaceutical biodegradation products in environmental samples.
Descripción9 pages, 2 figures, 1 table.-- Printed version published Dec 2007.-- Issue title: Emerging contaminants in wastewaters.
Versión del editorhttp://dx.doi.org/10.1016/j.trac.2007.10.005
URIhttp://hdl.handle.net/10261/10594
DOI10.1016/j.trac.2007.10.005
ISSN0167-2940
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