English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/10576
Compartir / Impacto:
Add this article to your Mendeley library MendeleyBASE
Citado 24 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar bibText (RIS)Exportar csv (RIS)

Life-history responses of Daphnia magna Straus to binary mixtures of toxic substances: Pharmacological versus ecotoxicological modes of action

Autor Barata Martí, Carlos; Baird, Donald J.; Nogueira, Antonio J. A.; Agra, Ana Raquel; Soares, Amadeu M. V. M.
Palabras clave Mixture toxicity
Mode of action
Fecha de publicación 30-oct-2007
Citación Aquatic Toxicology 84(4): 439-449 (2007)
ResumenTwo prevailing theoretical models: concentration addition (CA) and independent action (IA), predict mixture toxicity on the basis of known toxicities of the mixture components. To date, both models have been in most occasions evaluated using unicellular in vivo responses or biochemical in vitro responses. However, when considering more complex models such as the whole organism physiology or life-history traits, the dominant ecotoxicological mode of action, based on the exposure concentrations at which various toxicological effects become operative at the level of whole organism, should be considered. Offspring production in Daphnia magna is driven by the resources acquired from food, and the number of live offspring produced by an organism is the result of two independent factors: the number of eggs produced and the percentage of eggs that survive egg development. In this study joint toxicity effects on offspring production in D. magna were tested using binary mixtures of toxic contaminants known to specifically impair food acquisition (λ-cyhalothrin and cadmium) or to cause egg mortality during development (3,4 dichloroaniline). Tests were performed using a simplified 10-day reproduction assay initiated with gravid females. The results obtained indicate that irrespective of their primary pharmacological mode of action, the joint toxicity of cadmium and λ-cyhalothrin was predicted by the CA model, whereas the joint toxicity of cadmium and 3,4 dichloroaniline was predicted by the IA model. Thus, the results obtained indicate that for life-history traits such as reproduction responses, the dominant ecotoxicological rather than the pharmacological mode of action should be used for predicting joint mixture effects.
Descripción 11 pages, 3 tables, 4 figures.-- PMID: 17720258 [PubMed].
Versión del editorhttp://dx.doi.org/10.1016/j.aquatox.2007.07.004
URI http://hdl.handle.net/10261/10576
Aparece en las colecciones: (IDAEA) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.